{"id":809,"date":"2025-08-08T23:36:00","date_gmt":"2025-08-08T23:36:00","guid":{"rendered":"https:\/\/csbweb.csb.pitt.edu\/Faculty\/lee\/?p=809"},"modified":"2025-12-03T17:02:35","modified_gmt":"2025-12-03T17:02:35","slug":"paper-published-in-nature-communications","status":"publish","type":"post","link":"https:\/\/csbweb.csb.pitt.edu\/Faculty\/lee\/?p=809","title":{"rendered":"Paper published in Nature Communications!"},"content":{"rendered":"\n\n\n<p>Huge applause to Steven W. Smeal, Dr. Chaitanya S. Mokashi, A. Hyun (Annie) Kim, and P. Murdo Chiknas for publishing a monolith project of a paper, online now at <a href=\"_wp_link_placeholder\" data-wplink-edit=\"true\">this link<\/a>. This study shows that temporally patterned cytokine signals prolong IKK assemblies and disproportionately enhance nuclear NF-kB retention. Through microfluidics and modeling, it is revealed that this emergent behavior arises from NF-kB-dependent chromatin remodeling, with simulations indicating that most cell-to-cell variability originates at the level of receptor-associated complexes.\u00a0<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Huge applause to Steven W. Smeal, Dr. Chaitanya S. Mokashi, A. Hyun (Annie) Kim, and P. Murdo Chiknas for publishing a monolith project of a paper, online now at this&hellip; <\/p>\n","protected":false},"author":13,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[5],"tags":[],"class_list":["post-809","post","type-post","status-publish","format-standard","hentry","category-news"],"_links":{"self":[{"href":"https:\/\/csbweb.csb.pitt.edu\/Faculty\/lee\/index.php?rest_route=\/wp\/v2\/posts\/809","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/csbweb.csb.pitt.edu\/Faculty\/lee\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/csbweb.csb.pitt.edu\/Faculty\/lee\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/csbweb.csb.pitt.edu\/Faculty\/lee\/index.php?rest_route=\/wp\/v2\/users\/13"}],"replies":[{"embeddable":true,"href":"https:\/\/csbweb.csb.pitt.edu\/Faculty\/lee\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=809"}],"version-history":[{"count":1,"href":"https:\/\/csbweb.csb.pitt.edu\/Faculty\/lee\/index.php?rest_route=\/wp\/v2\/posts\/809\/revisions"}],"predecessor-version":[{"id":810,"href":"https:\/\/csbweb.csb.pitt.edu\/Faculty\/lee\/index.php?rest_route=\/wp\/v2\/posts\/809\/revisions\/810"}],"wp:attachment":[{"href":"https:\/\/csbweb.csb.pitt.edu\/Faculty\/lee\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=809"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/csbweb.csb.pitt.edu\/Faculty\/lee\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=809"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/csbweb.csb.pitt.edu\/Faculty\/lee\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=809"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}