{"id":829,"date":"2025-12-03T17:04:29","date_gmt":"2025-12-03T17:04:29","guid":{"rendered":"https:\/\/csbweb.csb.pitt.edu\/Faculty\/lee\/?p=829"},"modified":"2025-12-03T17:04:29","modified_gmt":"2025-12-03T17:04:29","slug":"paper-published-in-cell-reports","status":"publish","type":"post","link":"https:\/\/csbweb.csb.pitt.edu\/Faculty\/lee\/?p=829","title":{"rendered":"Paper published in Cell Reports!"},"content":{"rendered":"<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><a href=\"https:\/\/csbweb.csb.pitt.edu\/Faculty\/lee\/wp-content\/uploads\/2025\/12\/cellReports_graphicalAbstract.jpg\"><img loading=\"lazy\" decoding=\"async\" width=\"375\" height=\"375\" src=\"https:\/\/csbweb.csb.pitt.edu\/Faculty\/lee\/wp-content\/uploads\/2025\/12\/cellReports_graphicalAbstract.jpg\" alt=\"\" class=\"wp-image-831\" srcset=\"https:\/\/csbweb.csb.pitt.edu\/Faculty\/lee\/wp-content\/uploads\/2025\/12\/cellReports_graphicalAbstract.jpg 375w, https:\/\/csbweb.csb.pitt.edu\/Faculty\/lee\/wp-content\/uploads\/2025\/12\/cellReports_graphicalAbstract-300x300.jpg 300w, https:\/\/csbweb.csb.pitt.edu\/Faculty\/lee\/wp-content\/uploads\/2025\/12\/cellReports_graphicalAbstract-150x150.jpg 150w\" sizes=\"auto, (max-width: 375px) 100vw, 375px\" \/><\/a><\/figure><\/div>\n\n\n<p>Congratulations to A. Hyun (Annie) Kim, Ben Krummenacher, and Jason Yeung on this new publication, available online at <a href=\"https:\/\/www.cell.com\/cell-reports\/fulltext\/S2211-1247(25)01409-3\">this link<\/a>. In this study, we followed individual receptor signaling complexes as they assembled and disassembled in real time, comparing cellular responses to IL-1 cytokine orthologues separated by over 100 million years of evolution. Despite large differences in ligand\u2013receptor affinity across species, each signaling complex produced a discrete, quantized packet of signaling flux rather than a graded output\u2014revealing a conserved unit of information transfer within the pathway.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Congratulations to A. Hyun (Annie) Kim, Ben Krummenacher, and Jason Yeung on this new publication, available online at this link. In this study, we followed individual receptor signaling complexes as&hellip; <\/p>\n","protected":false},"author":13,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[5],"tags":[],"class_list":["post-829","post","type-post","status-publish","format-standard","hentry","category-news"],"_links":{"self":[{"href":"https:\/\/csbweb.csb.pitt.edu\/Faculty\/lee\/index.php?rest_route=\/wp\/v2\/posts\/829","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/csbweb.csb.pitt.edu\/Faculty\/lee\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/csbweb.csb.pitt.edu\/Faculty\/lee\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/csbweb.csb.pitt.edu\/Faculty\/lee\/index.php?rest_route=\/wp\/v2\/users\/13"}],"replies":[{"embeddable":true,"href":"https:\/\/csbweb.csb.pitt.edu\/Faculty\/lee\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=829"}],"version-history":[{"count":2,"href":"https:\/\/csbweb.csb.pitt.edu\/Faculty\/lee\/index.php?rest_route=\/wp\/v2\/posts\/829\/revisions"}],"predecessor-version":[{"id":832,"href":"https:\/\/csbweb.csb.pitt.edu\/Faculty\/lee\/index.php?rest_route=\/wp\/v2\/posts\/829\/revisions\/832"}],"wp:attachment":[{"href":"https:\/\/csbweb.csb.pitt.edu\/Faculty\/lee\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=829"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/csbweb.csb.pitt.edu\/Faculty\/lee\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=829"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/csbweb.csb.pitt.edu\/Faculty\/lee\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=829"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}