Huge applause to Steven W. Smeal, Dr. Chaitanya S. Mokashi, A. Hyun (Annie) Kim, and P. Murdo Chiknas for publishing a monolith project of a paper, online now at this link. This study shows that temporally patterned cytokine signals prolong IKK assemblies and disproportionately enhance nuclear NF-kB retention. Through microfluidics and modeling, it is revealed that this emergent behavior arises from NF-kB-dependent chromatin remodeling, with simulations indicating that most cell-to-cell variability originates at the level of receptor-associated complexes.