A review coauthored by Dr Xing in memory of Dr George Oster accepted in MBoC
Over the past 50 years, the use of mathematical models, derived from physical reasoning, to describe molecular and cellular systems has evolved from an art of the few to a cornerstone of biological inquiry. George Oster stood out as a pioneer of this paradigm shift from descriptive to quantitative biology not only through his numerous […]
a paper first authored by Manju and Xiaojun accepted in Cancer Research
Targeting microenvironmental factors that foster migratory cell phenotypes is a promising strategy for halting tumor migration. However, lack of mechanistic understanding of the emergence of migratory phenotypes impedes pharmaceutical drug development. Using our 3D microtumor model with tight control over tumor size, we recapitulated tumor size-induced hypoxic microenvironment and emergence of migratory phenotypes in epithelial […]
Our lab presented at the 2019 APS March meeting
Dr Weikang Wang and Dr Xing gave two contributed talks, and our former postdoc Dr Xiaojun Tian gave an invited talk on several projects done in the lab.
Our review on EMT is accepted in Physical Biology.
This is a review that appear in a focused issue of Physical Biology on EMT,
Dr Xing talked at Gordon conference “Statistical Physics in Biology”
Dr Xing presented our work on reconstructing cell dynamics from single cell trajectories.
Jingyu’s paper accepted in PLoS Comp Biol
Many cellular responses to surrounding cues require temporally concerted transcriptional regulation of multiple genes. In prokaryotic cells a single-input-module motif with one transcription factor regulating multiple target genes can generate coordinated gene expression. In eukaryotic cells, transcriptional activity of a gene is affected by not only transcription factors but also the ambient DNA condition of […]
Jackie and Yaxuan joined the lab as undergraduate researchers
Jackie has been with us as a trainee and volunteer for a year. Yaxuan is new. Now they become formal group members. Welcome!
Undergraduate researcher Maddie graduated from Pitt
It has been three years since Maddie joined the lab. Good luck on your new chapter of life!
Dr Xing receives a new R01 grant from NIDDK
https://csbweb.csb.pitt.edu/dr-xing-pi-and-dr-simon-watkins-co-i-receive-r01-award-from-niddk/