Conformational Dynamics of Proteins

Research Objective: Predicting the collective motions and thereby functional mechanisms from structural information
Direct evaluation of thermal fluctuations in proteins using a single-parameter harmonic potential (abstract) (.pdf)

Links:

Brief Description of the Gaussian Network Model (GNM)
GNM Server and Database
Dependence of Effective Force Constants on Protein Size
GNM References

Movies (.mov are viewed with Quicktime):

GroEL (.mov 319 KB)
HIV-1 Reverse Transciptase (.mov 265 KB)
c-Src Kinase (.mov 365 KB)

Protein Science Volume 7, Number 12 - December 1998
Article (HTML)

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